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The Optogenetics APP What is the Optogenetics
APP? The Optogenetics APP is a
tool to aid an investigator in estimating the required optical power for a
given in-vivo experiment involving optogenetics or any other
experimental approach that includes light delivery to deep brain areas via
optical fibers. Different brain areas have
different optical properties, which determine how light scatters and
distributes (and how deeply it penetrates the tissue), once it exits the
fiber. The APP has a complete mouse brain atlas included that can be used to
determine the optical properties of any brain area in the mouse brain. A user
finds the brain areas of choice, marks it on the atlas, then tell the APP
what type of optogenetic protein he/she wants to use, as well as the type of
optical fiber, desired optical power, and desired protein activation ratio. Based on these parameters, the APP
estimates how far the light will spread in this particular experimental
situation (and thus, up to which distance from the fiber tip optogenetic
protein activation can be expected). For a detailed description of the
underlying experimental data, the experimental approach, and an explanation
of the optical equations, please see the following peer-reviewed journal article: Al-Juboori
et al: Light scattering properties differ
between different areas of the adult mouse brain. PlosONE, publication e67626, published July 9, 2013. This manuscript is open
access (i.e. can be downloaded free of charge through the link shown above), once it is published. How do I get the Optogenetics
APP? The application is currently
available for iOS only. It is compatible with
iPhones, iPads, and certain iPods. Download
Optogenetics (the free version) from iTunes Download
Optogenetics Pro (the paid version) from iTunes Versions for Android and web
browsers will be coming shortly! Popneuron Limited 3700 Quebec Street Unit 100-121 Denver, CO 80207-1639 U.S.A. www.popneuron.com info@popneuron.com |
